The Journal of Systems Biology is an open source journal communicating original research, theory, and perspectives on all aspects of biocomplexity. The defining focus of the journal is the emphasis on biological entities as multi-component systems, whose parts interact in definable and interesting ways. The constructive interplay between reductionism and holism is emphasized, along with the centrality of integrative approaches in the study of emergence of function in complex biological systems. The biological scope is broad and ranges in spatial scale from the genome and cell up to the ecosystem and globe, and taxonomically includes both non-human and human systems. The journal is especially interested in articles in the following areas:
Methodological Domains
-    Network biology
-    Matrix models of complex biological systems
-    Computational modeling of complex biological sys    tems
-    Theoretical studies of biocomplexity
-    Studies of power-law scaling, fractals, and 1/f noise in biological systems
-    New and novel approaches to studying biocomplexity
-    Methods and tools for teaching systems biology
Topical Domains
Genomes and cellular information systems
Molecular systems biology
Cellular systems biology
Organisms as developmental systems
Organisms as physiological systems
Medical systems biology
Ecological and environmental systems
Human cultural and technological systems
Information entropy and natural language systems
History and philosophy of systems biology
All contributions shall be rigorously refereed and selected on the basis of quality and originality of the work as well as the breadth of interest to readers.